Complex From Crispr-cas Gene Editing System
by Carlos Clarivan/science Photo Library
Title
Complex From Crispr-cas Gene Editing System
Artist
Carlos Clarivan/science Photo Library
Medium
Photograph - Photograph
Description
Complex from CRISPR-Cas gene editing system, molecular structure. Shown here is the Cas6-RNA maturation adaptation phase, part of the CRISPR-Cas prokaryotic immune system. CRISPR-Cas complexes are used in genome engineering to cut DNA (deoxyribonucleic acid). Here, the effector RNA (orange) is bound to the Cas6/cse3 protein (light blue) during the expression phase in the Thermus thermophilus bacterium. Resistance to phage infection is conferred in prokaryotes by the incorporation of short invading DNA sequences into the genome as spacer elements separated by short repeat sequences. Processing of long primary transcripts (pre-crRNAs) containing these repeats by RNA endonucleases such as Cas6 generates the mature effector RNAs that interfere with bacteriophage gene expression.
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February 15th, 2021
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