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Molecular model of caspase-1 complexed with an inhibitor. Caspase-1 is a protease, an enzyme that cleaves proteins. It is found predominantly in the cell cytoplasm, where it activates interleukin-1-beta, a molecule that mediates immune and inflammatory responses. Due to this activity caspase-1 is also known as ICE (interleukin-1-beta converting enzyme). Like other caspases it also plays a role in apoptosis (programmed cell death), but only when over-expressed.

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