G Protein-coupled Receptors #1
by Science Photo Library
Title
G Protein-coupled Receptors #1
Artist
Science Photo Library
Medium
Photograph - Photograph
Description
Molecular model of four G-protein-coupled receptors (GPCRs). From left to right the GPCRs are; rhodopsin, which is activated by absorbing light, T-cell receptor, which is activated by a major histocompatibility complex (MHC) class II molecule presenting an antigen (green), dopamine receptor, which is activated by dopamine (red), and gamma-aminobutyric acid receptor B (GABA-B receptor), being activated by the agonist drug baclofen. Activation of the receptors triggers a signalling cascade. In rhodopsin this is occurs when the GPCR's alpha subunit (light blue) activates phosphodiesterase 6, which breaks down cyclic guanosine monophosphate (cGMP) and leads to sodium channels closing. The other GPCRs activate the enzyme adenylyl cyclase, which produces cyclic adenosine monophosphate (cAMP). cAMP activates protein kinase C, which regulates numerous cell functions.
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May 10th, 2022
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